View Full Chapter Figures Only Tables Only Videos Only Print Share Email Twitter Facebook Linkedin Reddit Get Citation Citation AMA Citation Vernon H. Vernon H Vernon, Hilary. "CoEnzyme Q10 deficiency leads to downstream disruption of sulfide metabolism." OMMBID Blog, 9 December 2016. McGraw-Hill, New York, NY, 2016. OMMBID. http://ommbid.mhmedical.com/updatesContent.aspx?gbosid=324365§ionid=147640697 MLA Citation Vernon H. Vernon H Vernon, Hilary.. "CoEnzyme Q10 deficiency leads to downstream disruption of sulfide metabolism." OMMBID Blog New York, NY: McGraw-Hill, 2016, http://ommbid.mhmedical.com/updatesContent.aspx?gbosid=324365§ionid=147640697. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Tools Top Return Clip Autosuggest Results CoEnzyme Q10 deficiency leads to downstream disruption of sulfide metabolism by Hilary Vernon, MD PhD, Assistant Professor of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University + +Luna-Sanchez et al (EMBO Molecular Medicine, November 2016, pii: e201606345. doi: 10.15252/emmm.201606345) recently published an article in which they described downstream effects of CoEnzyme Q10 deficiency in both a fibroblast model and two mouse models of primary CoQ10 deficiency. This group uncovered alterations in thiol metabolism, and subsequent changes in the biosynthesis glutamate, serotonin and catecholamine metabolism. +Effects on sulfur metabolic pathways are increasingly implicated in models of mitochondrial disease, and represent an important direction for both research and potential therapeutic intervention. +Hilary Vernon, MD PhD