RT Book, Section
A1 Havel, Richard J.
A1 Kane, John P.
A2 Valle, David L.
A2 Antonarakis, Stylianos
A2 Ballabio, Andrea
A2 Beaudet, Arthur L.
A2 Mitchell, Grant A.
SR Print(0)
ID 1181441818
T1 Introduction: Structure and Metabolism of Plasma Lipoproteins
T2 The Online Metabolic and Molecular Bases of Inherited Disease
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071459969
LK ommbid.mhmedical.com/content.aspx?aid=1181441818
RD 2024/04/25
AB Although  it  was  appreciated  at  the  turn  of  the  century  that  the  lipids  of  plasma  are  solubilized  by  protein,1  it  was  another  28  years  before  the  first  lipoproteins,  high-density  lipoproteins  (HDL),  were  isolated.2  During  the  comprehensive  efforts  to  isolate  human  plasma  proteins  during  World  War  II,  lipoproteins  of  low  density  and  β  electrophoretic  mobility  were  clearly  identified  and  separated  from  HDL  with  α  mobility.3  Within  the  next  decade,  the  major  antigenic  determinants  of  α  and  β  lipoproteins  were  shown  to  be  distinct.4,5  Studies  of  their  hydrodynamic  behavior  demonstrated  the  existence  of  the  larger,  less  dense,  very  low  density  lipoproteins  (VLDL)  and  intermediate  density  lipoproteins  (IDL);6  it  was  established  that  a  strongly  antigenic  protein  was  common  to  these  lipoproteins  and  low  density  lipoproteins  (LDL).7  The  presence  of  glutamic  acid  as  the  principal  N-terminus  in  LDL8,9  and  one  of  several  in  VLDL10  gave  chemical  support  to  the  concept  that  one  protein,  distinct  from  the  principal  proteins  in  HDL,  is  virtually  the  only  apolipoprotein  in  LDL  and  is  present  in  significant  amounts  with  other  apolipoproteins  in  VLDL.  This  common  protein  constituent  of  LDL  and  its  lipoprotein  precursors  was  termed  “apolipoprotein  (apo)  B”  to  distinguish  it  from  the  protein  moiety  of  HDL  (apo  A)  and  the  newly  recognized  proteins  of  VLDL  (apo  C).