RT Book, Section A1 Cahill, Daniel P. A1 Lengauer, Christoph A2 Valle, David L. A2 Antonarakis, Stylianos A2 Ballabio, Andrea A2 Beaudet, Arthur L. A2 Mitchell, Grant A. SR Print(0) ID 1181413370 T1 Tumor Genome Instability T2 The Online Metabolic and Molecular Bases of Inherited Disease YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071459969 LK ommbid.mhmedical.com/content.aspx?aid=1181413370 RD 2024/03/28 AB Genetic instability has long been recognized as a cardinal feature of neoplasia.1,2 However, the causal role of genetic instability in the formation of cancer has only more recently been studied. Accumulating evidence has strengthened the proposal that genetic instability is required early during tumor progression. Instability drives mutations in oncogenes and tumor suppressor genes, providing the tumor cell with a selective growth advantage.3 While numerous oncogenes and tumor suppressor genes have been identified in the last 20 years, the molecular details underlying genetic instability are just now being revealed.