RT Book, Section
A1 Fugger, Lars
A1 Tisch, Roland
A1 Libau, Roland
A1 van Endert, Peter
A1 McDevitt, Hugh O.
A2 Valle, David L.
A2 Antonarakis, Stylianos
A2 Ballabio, Andrea
A2 Beaudet, Arthur L.
A2 Mitchell, Grant A.
SR Print(0)
ID 1181402186
T1 The Role of Human Major Histocompatibility Complex (HLA) Genes in Disease
T2 The Online Metabolic and Molecular Bases of Inherited Disease
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071459969
LK ommbid.mhmedical.com/content.aspx?aid=1181402186
RD 2024/09/08
AB The  human  major  histocompatibility  complex  (MHC),  also  designated  the  human  leukocyte  antigen  (HLA)  system,  was  initially  characterized  using  maternal  antisera  that  identified  paternal  transplantation  antigens  expressed  in  the  offspring.  HLA  typing  was  originally  developed  to  facilitate  organ  and  tissue  transplantation,  particularly  renal  transplantation.  The  discovery  that  the  ability  of  mice  to  make  an  immune  response  to  synthetic  polypeptides  was  linked  to  the  murine  MHC,  designated  H-2,1  and  the  earlier  demonstration  that  susceptibility  to  Gross-virus-induced  leukemogenesis  was  also  linked  to  H-2,2  stimulated  a  search  for  direct  or  indirect  effects  of  MHC  genes  on  susceptibility  to  many  different  diseases.