RT Book, Section
A1 Todd, John A.
A2 Valle, David L.
A2 Antonarakis, Stylianos
A2 Ballabio, Andrea
A2 Beaudet, Arthur L.
A2 Mitchell, Grant A.
SR Print(0)
ID 1181401243
T1 Multifactorial Diseases: Ancient Gene Polymorphism at Quantitative Trait Loci and a Legacy of Survival During Our Evolution
T2 The Online Metabolic and Molecular Bases of Inherited Disease
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071459969
LK ommbid.mhmedical.com/content.aspx?aid=1181401243
RD 2024/04/23
AB Most  genetic  diseases  do  not  follow  a  Mendelian  paradigm;  instead  they  are  multifactorial  having  biological  components  that  are  both  in  the  host  (biological  variation)  and  in  the  environment  (exposure  to  experiences  that  are  selective  and  impinge  on  health).  In  addition  to  alleles  that  confer  susceptibility  (for  resistance)  under  certain  conditions,  there  could  be  a  constellation  of  alleles  at  different  loci  affecting  proteins  that  must  interact,  in  this  way  accounting  for  a  complex  trait.  This  chapter  addresses,  in  a  brief  way,  how  one  begins  to  approach  mapping  the  genomic  bases  of  complex  traits.