TY  - CHAP
M1  - Book, Section
TI  - Tumor Genome Instability
A1  - Cahill, Daniel P.
A1  - Lengauer, Christoph
A2  - Valle, David L.
A2  - Antonarakis, Stylianos
A2  - Ballabio, Andrea
A2  - Beaudet, Arthur L.
A2  - Mitchell, Grant A.
PY  - 2019
T2  - The Online Metabolic and Molecular Bases of Inherited Disease
AB  - Genetic  instability  has  long  been  recognized  as  a  cardinal  feature  of  neoplasia.1,2  However,  the  causal  role  of  genetic  instability  in  the  formation  of  cancer  has  only  more  recently  been  studied.  Accumulating  evidence  has  strengthened  the  proposal  that  genetic  instability  is  required  early  during  tumor  progression.  Instability  drives  mutations  in  oncogenes  and  tumor  suppressor  genes,  providing  the  tumor  cell  with  a  selective  growth  advantage.3  While  numerous  oncogenes  and  tumor  suppressor  genes  have  been  identified  in  the  last  20  years,  the  molecular  details  underlying  genetic  instability  are  just  now  being  revealed.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - ommbid.mhmedical.com/content.aspx?aid=1181413370
ER  -