TY  - CHAP
M1  - Book, Section
TI  - Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
A1  - Richard Boland, C.
A2  - Valle, David L.
A2  - Antonarakis, Stylianos
A2  - Ballabio, Andrea
A2  - Beaudet, Arthur L.
A2  - Mitchell, Grant A.
Y1  - 2019
N1  - 10.1036/ommbid.333
T2  - The Online Metabolic and Molecular Bases of Inherited Disease
AB  - Colorectal  cancer  is  a  fairly  common  disease  of  Western  populations  with  a  typical  onset  at  about  age  70  years.  The  international  epidemiology  of  this  disease  suggests  that  environmental  factors,  probably  dietary,  are  the  most  important  influences  for  the  high  prevalence  of  this  disease  in  certain  countries.1  Woven  into  the  epidemiologic  fabric  for  colorectal  cancer  is  an  important  influence  of  genetic  factors.  Individuals  who  have  even  one  first-degree  relative  with  colorectal  neoplasia  (i.e.,  either  cancers  or  adenomatous  polyps)  have  an  increased  risk  for  these  tumors  themselves,  which  will  appear  earlier  in  life.2-4  The  familial  risk  increases  when  there  is  more  than  one  family  member  involved  or  cancers  occur  before  age  50.3,4  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
M3  - doi: 10.1036/ommbid.333
Y2  - 2024/04/23
UR  - ommbid.mhmedical.com/content.aspx?aid=1181414468
ER  -