TY - CHAP M1 - Book, Section TI - Mendelian Hypophosphatemias A1 - Sabbagh, Yves A1 - Tenenhouse, Harriet S. A1 - Econs, Michael J. A1 - Auricchio, Alberto A2 - Valle, David L. A2 - Antonarakis, Stylianos A2 - Ballabio, Andrea A2 - Beaudet, Arthur L. A2 - Mitchell, Grant A. PY - 2019 T2 - The Online Metabolic and Molecular Bases of Inherited Disease AB - Inorganic phosphate is an essential nutrient in terms of both cell function and skeletal mineralization. It is required for glycolysis, gluconeogenesis, and energy metabolism, as well as for the synthesis of DNA, RNA, membrane phospholipids, and a variety of phosphorylated intermediates. In addition, the phosphorylation of cellular proteins is a major mechanism by which cell function is controlled. Intracellular regulatory roles for the inorganic phosphate anion involve such diverse functions as control of aerobic metabolism, control of the O2 dissociation curve of hemoglobin in the intact red blood cell, and regulation of cellular calcium metabolism. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - ommbid.mhmedical.com/content.aspx?aid=1181473691 ER -