TY - CHAP M1 - Book, Section TI - The Role of Human Major Histocompatibility Complex (HLA) Genes in Disease A1 - Fugger, Lars A1 - Tisch, Roland A1 - Libau, Roland A1 - van Endert, Peter A1 - McDevitt, Hugh O. A2 - Valle, David L. A2 - Antonarakis, Stylianos A2 - Ballabio, Andrea A2 - Beaudet, Arthur L. A2 - Mitchell, Grant A. PY - 2019 T2 - The Online Metabolic and Molecular Bases of Inherited Disease AB - The human major histocompatibility complex (MHC), also designated the human leukocyte antigen (HLA) system, was initially characterized using maternal antisera that identified paternal transplantation antigens expressed in the offspring. HLA typing was originally developed to facilitate organ and tissue transplantation, particularly renal transplantation. The discovery that the ability of mice to make an immune response to synthetic polypeptides was linked to the murine MHC, designated H-2,1 and the earlier demonstration that susceptibility to Gross-virus-induced leukemogenesis was also linked to H-2,2 stimulated a search for direct or indirect effects of MHC genes on susceptibility to many different diseases. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - ommbid.mhmedical.com/content.aspx?aid=1181402186 ER -