TY  - CHAP
M1  - Book, Section
TI  - Multifactorial Diseases: Ancient Gene Polymorphism at Quantitative Trait Loci and a Legacy of Survival During Our Evolution
A1  - Todd, John A.
A2  - Valle, David L.
A2  - Antonarakis, Stylianos
A2  - Ballabio, Andrea
A2  - Beaudet, Arthur L.
A2  - Mitchell, Grant A.
PY  - 2019
T2  - The Online Metabolic and Molecular Bases of Inherited Disease
AB  - Most  genetic  diseases  do  not  follow  a  Mendelian  paradigm;  instead  they  are  multifactorial  having  biological  components  that  are  both  in  the  host  (biological  variation)  and  in  the  environment  (exposure  to  experiences  that  are  selective  and  impinge  on  health).  In  addition  to  alleles  that  confer  susceptibility  (for  resistance)  under  certain  conditions,  there  could  be  a  constellation  of  alleles  at  different  loci  affecting  proteins  that  must  interact,  in  this  way  accounting  for  a  complex  trait.  This  chapter  addresses,  in  a  brief  way,  how  one  begins  to  approach  mapping  the  genomic  bases  of  complex  traits.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - ommbid.mhmedical.com/content.aspx?aid=1181401243
ER  -