Skip to Main Content


  1. Cylindromas are benign neoplasms of the skin that originate from skin appendage structures. Sporadic cylindromas are usually small, solitary tumors with few complications. Familial cylindromatosis is a rare, autosomal dominant genetic predisposition to the development of multiple cylindromas. This can be a severely disfiguring condition associated with considerable morbidity.

  2. There is a single familial cylindromatosis susceptibility gene (CYLD) located on chromosome 16q12. Loss of heterozygosity on chromosome 16q in both familial and sporadic cylindromas indicates that CYLD is a tumor-suppressor gene/recessive oncogene. Germ line mutations of CYLD are found in cylindromatosis families and somatic mutations in sporadic and familial cylindromas. However, no somatic mutations have been found in other types of neoplasm. All currently identified mutations are predicted to cause truncation or absence of the encoded protein.

  3. CYLD encodes a 956-amino acid protein. It includes three Cytoskeletal-Associated Protein-Glycine conserved (CAP-GLY) domains that are found in proteins coordinating the attachment of organelles to microtubules. It also has sequence homology to the catalytic domain of ubiquitin C-terminal hydrolases, a family of enzymes that act to deubiquitinate proteins. However, the critical biological activities that are subverted by the CYLD mutations that result in cylindromatosis have yet to be elucidated.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.