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Abstract

Abstract  Genetic instability has long been recognized as a cardinal feature of neoplasia.1, 2 However, the causal role of genetic instability in the formation of cancer has only more recently been studied. Accumulating evidence has strengthened the proposal that genetic instability is required early during tumor progression. Instability drives mutations in oncogenes and tumor suppressor genes, providing the tumor cell with a selective growth advantage.3 While numerous oncogenes and tumor suppressor genes have been identified in the last 20 years, the molecular details underlying genetic instability are just now being revealed.

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